Rygnestad T, Zahlsen K, Samdal F A
Department of Clinical Pharmacology and Pharmacy, The Regional and University Hospital in Trondheim, Norway.
Eur J Clin Pharmacol. 2000 May;56(2):141-3. doi: 10.1007/s002280050732.
The aim of this study was to compare the rate of absorption between ordinary paracetamol tablets and effervescent paracetamol tablets.
Twenty healthy volunteers participated in an open randomised crossover study and were given a 1000-mg dose of either ordinary paracetamol tablets (2 x 500 mg Panodil tablets, SmithKline Beecham) or effervescent paracetamol tablets (2 x 500 mg Pinex Brusetablett, Alpharma AS) with a 3-week washout period in between. Blood samples were collected for 3 h. Maximum serum concentration (Cmax) and the time to maximum serum concentration (tmax) were recorded and the area under the concentration versus time curve (AUC) was calculated.
The mean tmax was significantly shorter when paracetamol effervescent tablets were taken (27 min) rather than ordinary paracetamol tablets (45 min) (P = 0.004). There was no significant difference between the mean Cmax of 143 micromol/l with effervescent tablets and that of 131 micromol/l with ordinary tablets. The mean AUC(0-3 h) was significantly higher with paracetamol effervescent tablets (223.8 micromol x h x l(-1)) than with ordinary tablets (198.2 micromol x h x l(-1); P = 0.003). After 15 min, 17 (85%) subjects in the effervescent group had a serum concentration of 70 micromol/l (lower therapeutic serum concentration) or higher relative to only 2 (10%) subjects in the ordinary tablet group (P = 0.001).
Paracetamol effervescent tablets are absorbed significantly faster than ordinary paracetamol. Thus, effervescent tablets might offer significantly faster pain relief when paracetamol is used.
本研究旨在比较普通对乙酰氨基酚片与泡腾对乙酰氨基酚片的吸收速率。
20名健康志愿者参与了一项开放随机交叉研究，分别给予1000毫克剂量的普通对乙酰氨基酚片（2片500毫克的必理通片，史克必成公司）或泡腾对乙酰氨基酚片（2片500毫克的Pinex Brusetablett，阿尔法制药公司），中间间隔3周的洗脱期。采集血样3小时。记录最大血清浓度（Cmax）和达到最大血清浓度的时间（tmax），并计算浓度-时间曲线下面积（AUC）。
服用泡腾对乙酰氨基酚片时的平均tmax（27分钟）明显短于普通对乙酰氨基酚片（45分钟）（P = 0.004）。泡腾片的平均Cmax为143微摩尔/升，普通片为131微摩尔/升，两者之间无显著差异。对乙酰氨基酚泡腾片的平均AUC(0 - 3小时)（223.8微摩尔·小时·升⁻¹）明显高于普通片（198.2微摩尔·小时·升⁻¹；P = 0.003）。15分钟后，泡腾片组有17名（85%）受试者的血清浓度达到70微摩尔/升（较低治疗血清浓度）或更高，而普通片组只有2名（10%）受试者达到该浓度（P = 0.001）。
泡腾对乙酰氨基酚片的吸收明显快于普通对乙酰氨基酚片。因此，使用对乙酰氨基酚时，泡腾片可能能显著更快地缓解疼痛。
