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健康大脑中人类疱疹病毒8型的存在及分布调查。

Survey for the presence and distribution of human herpesvirus 8 in healthy brain.

作者信息

Chan P K, Ng H K, Cheung J L, Cheng A F

机构信息

Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China.

出版信息

J Clin Microbiol. 2000 Jul;38(7):2772-3. doi: 10.1128/JCM.38.7.2772-2773.2000.

DOI:10.1128/JCM.38.7.2772-2773.2000
PMID:10878085
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC87028/
Abstract

Brain tissues from both sides of the cerebellum and frontal, temporal, parietal, and occipital lobes were collected postmortem from 30 patients for human herpesvirus 8 (HHV-8) detection by PCR. Overall, 42 of 300 (14.0%) samples were positive, with similar rates for each position. Nineteen patients (63.3%) were positive and showed a significant increase in positivity with age (P = 0.007). The results indicate a neuroinvasive and neuropersistent potential of HHV-8.

摘要

对30例患者进行尸检，采集其小脑两侧以及额叶、颞叶、顶叶和枕叶的脑组织，采用聚合酶链反应（PCR）检测人疱疹病毒8型（HHV-8）。总体而言，300个样本中有42个（14.0%）呈阳性，各部位阳性率相似。19例患者（63.3%）呈阳性，且阳性率随年龄显著增加（P = 0.007）。结果表明HHV-8具有神经侵袭和神经持续性潜力。