Young M, Funder J W
Baker Medical Research Institute, PO Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia.
Trends Endocrinol Metab. 2000 Aug;11(6):224-6. doi: 10.1016/s1043-2760(00)00270-8.
Classically, aldosterone is a steroid hormone secreted from the adrenal cortex, which acts on kidney, colon and sweat/salivary glands to promote unidirectional sodium transport. Currently, there is excellent experimental evidence for aldosterone acting directly on the central nervous system to raise blood pressure, and on the heart to cause cardiac hypertrophy and fibrosis. In addition, there is emerging evidence for aldosterone synthesis in the heart, and for as yet unexplained benefits of aldosterone antagonism in the treatment of cardiac failure.
传统上，醛固酮是一种从肾上腺皮质分泌的类固醇激素，作用于肾脏、结肠以及汗腺/唾液腺，促进单向钠转运。目前，有充分的实验证据表明醛固酮可直接作用于中枢神经系统以升高血压，还可作用于心脏导致心肌肥厚和纤维化。此外，越来越多的证据表明心脏中存在醛固酮合成，且醛固酮拮抗剂在治疗心力衰竭方面有尚未得到解释的益处。
