嵌合小鼠体内肿瘤生长增强。
Enhanced tumor growth in chimeric mice.
作者信息
Elbling L, Kurata T, Micksche M
出版信息
Oncology. 1976;33(4):157-60. doi: 10.1159/000225133.
PMID:1087971
Abstract
Chimeras were produced by aggregation of B6D2F1 and SWA early embryos. Lewis lung tumor, syngeneic in B6D2F1, was used to study tumor growth and metastases in these chimeras. Enhanced tumor growth, low metastases rate and pronounced enlarged spleen could be observed in SWA equilibrium B6D2F1 chimeras 21 days after inoculation of tumor cells. Increased activity of suppressor T-cells which might be due to permanent allogeneic stimulation in chimeras is discussed as one of the possible mechanisms.
摘要
通过B6D2F1和SWA早期胚胎聚集产生嵌合体。Lewis肺癌在B6D2F1中是同基因的，用于研究这些嵌合体中的肿瘤生长和转移。在接种肿瘤细胞21天后，在SWA平衡B6D2F1嵌合体中可观察到肿瘤生长增强、转移率低和脾脏明显肿大。讨论了抑制性T细胞活性增加可能是由于嵌合体中永久性异基因刺激所致，这是可能的机制之一。
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