García A, Gutiérrez M A, Barrasa J, Herranz J L
Services of Clinical Neurophysiology, University Hospital Marqués de Valdecila, Santander, Spain.
Seizure. 2000 Jun;9(4):297-300. doi: 10.1053/seiz.2000.0411.
Gelastic (laughing) seizures are an uncommon seizure type which in most cases has an organic cerebral pathology and specifically a hypothalamic hamartoma. The interictal EEG frequently shows focal activity. This report describes a 3 1/2-year-old boy who presented with episodes of unmotivated laughter associated with other epileptic symptomatology before the age of 3 years. Prolonged ambulatory EEG monitoring recorded electroclinical seizures starting in the right frontal area and spreading to the adjacent frontotemporal region. Neurological examination and brain magnetic resonance imaging were normal. Vigabatrin resulted in immediate remission of the seizures and normalization of the EEG.
痴笑性癫痫发作是一种不常见的癫痫发作类型，在大多数情况下存在器质性脑病变，具体为下丘脑错构瘤。发作间期脑电图常显示局灶性活动。本报告描述了一名3岁半的男孩，他在3岁前出现与其他癫痫症状相关的无诱因发笑发作。长时间动态脑电图监测记录到癫痫临床发作始于右侧额叶区域，并扩散至相邻的额颞叶区域。神经学检查和脑磁共振成像均正常。vigabatrin使癫痫发作立即缓解，脑电图恢复正常。
