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[情感诱发的额叶癫痫伴痴笑发作病例]

[Case of frontal lobe epilepsy with gelastic seizures induced by emotion].

作者信息

Yamazaki Yasuhiro, Sudo Akira, Ito Tomoshiro, Sano Hitomi, Fukushima Naoki

机构信息

Department of Pediatrics, Sapporo City General Hospital, 1-11, North 11 West 13, Chuo-ku, Sapporo, Hokkaido 060-8604, Japan.

出版信息

Brain Nerve. 2009 Aug;61(8):989-93.

Abstract

Gelastic seizures without hypothalamic hamartoma is a rare forms of epilepsy. Here, we report the case of 4-year-old girl with gelastic seizures. There was no delay in mental or motor development of the patient. The patient exhibited a peculiar seizure pattern that suddenly clung to her mother stiffening her body and an outburst of laughter with no apparent cause. The frequency of the seizures increased over a period of 1 month. Although the brain MRI and interictal EEG showed no abnormality, ictal EEG showed a 14 Hz wave discharge and subsequent slow-wave activity and suppression in bilateral frontal areas. The seizures responded favorably to oral administration of carbamazepine. The induction of the seizures could be related to theophylline administration and emotional excitation.

摘要

无下丘脑错构瘤的痴笑性癫痫是一种罕见的癫痫形式。在此,我们报告一例4岁患痴笑性癫痫的女孩。该患者的智力和运动发育无延迟。患者表现出一种特殊的发作模式,突然抱住她的母亲,身体僵硬,并毫无明显缘由地爆发出笑声。发作频率在1个月内增加。尽管脑部MRI和发作间期脑电图未显示异常,但发作期脑电图显示双侧额叶区域有14Hz波放电,随后出现慢波活动和抑制。口服卡马西平对发作有良好疗效。发作的诱发可能与茶碱给药和情绪激动有关。

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