Patricia Bacus Ioana, Haghighat Zahra, Raslau Flavius
Pediatrics, Child Neurology, University of Kentucky, United States.
Child Neurology, University of Kentucky, United States.
Epilepsy Behav Rep. 2023 Jun 6;23:100609. doi: 10.1016/j.ebr.2023.100609. eCollection 2023.
Gelastic seizure is a rare type of seizure characterized by bouts of uncontrolled, stereotyped laughter and often associated with hypothalamic hamartomas. In this case study we review a patient with a low grade ganglioglioma in the temporal lobe, a rare type of brain tumor that commonly causes seizures. The 8-year-old ambidextrous patient presented with seizures starting four days prior to presentation, happening multiple times daily and with each seizure lasting for 5-15 s. The patient's neurological examination was normal between episodes, and VEEG recorded ictal laughing events originating focally from the anterior temporal and/or inferior frontal region. Seizures were stopped with Levetiracetam, however given MRI findings surgical intervention was additionally deemed necessary. MRI head with contrast showed 8 mm nodular enhancing lesion located in the anteroventral portion of the right temporal pole with surrounding edema that extended to the anterior margin of the fusiform gyrus. The patient recovered well from surgery with no neurological deficits, is no longer on any antiseizure medications and remains seizure free at 3-year follow-up.
痴笑性癫痫是一种罕见的癫痫类型，其特征为阵发性不受控制的刻板笑声，常与下丘脑错构瘤相关。在本病例研究中，我们回顾了一名患有颞叶低级别神经节胶质瘤的患者，这是一种罕见的脑肿瘤，通常会引发癫痫。这名8岁的双手都很灵活的患者在就诊前四天开始出现癫痫发作，每天发作多次，每次发作持续5至15秒。发作间期患者的神经系统检查正常，视频脑电图记录到发作期的笑事件起源于前颞叶和/或额下回局部区域。使用左乙拉西坦控制了癫痫发作，但鉴于磁共振成像（MRI）结果，认为还需要进行手术干预。增强头颅MRI显示，一个8毫米的结节状强化病变位于右侧颞极的前腹侧部分，周围有水肿，延伸至梭状回的前缘。患者术后恢复良好，无神经功能缺损，不再服用任何抗癫痫药物，在3年随访中无癫痫发作。
