Jannuzzi C, Campelli A, Fabbri A
Boll Ist Sieroter Milan. 1976;55(6):519-23.
The Authors studied the amount of anti-measles and anti-rubella heteroantibodies during chronic hepatitis and the possible role of these antibodies in eliciting and maintaining the hypergammaglobulinemic picture, characteristic of this morbid condition. The results they obtained in an almost exclusively pediatric case-list (37 cases) show, whenever the contact with these viruses (measles and rubella) occurred, a percentage of subjects with comparatively higher levels among chronic liver patients in comparison with control patients, of the same age. The percentage of subjects with previous rubella infection and hemagglutination-inhibiting antibody levels higher than 1:256 is about 45% among chronic liver patients, compared with 13% in healthy subjects. As far as measles virus is concerned the percentage drops from 11% to 4%. The most reliable hypotheses to explain this interesting phenomenon, which, however, does explain only partially, and concerning some cases only, the entity of the hypergammaglobulineamia, are set forth briefly.
作者研究了慢性肝炎患者体内抗麻疹和抗风疹异种抗体的数量，以及这些抗体在引发和维持高球蛋白血症方面可能发挥的作用，高球蛋白血症是这种疾病状态的特征。他们在几乎全部为儿科病例（37例）中获得的结果表明，无论何时接触这些病毒（麻疹和风疹），与同龄对照患者相比，慢性肝病患者中抗体水平相对较高的受试者比例更高。在慢性肝病患者中，既往有风疹感染且血凝抑制抗体水平高于1:256的受试者比例约为45%，而健康受试者中这一比例为13%。就麻疹病毒而言，该比例从11%降至4%。文中简要阐述了一些最可靠的假设，用以解释这一有趣的现象，不过这些假设仅能部分解释，且仅针对部分病例，关于高球蛋白血症的情况。
