Orenstein W A, Herrmann K, Albrecht P, Bernier R, Holmgreen P, Bart K J, Hinman A R
Dev Biol Stand. 1986;65:75-83.
A statewide serosurvey was conducted among 6th, 10th and 12th grade Massachusetts schoolchildren in 1982. Sera were screened using a standard measles hemagglutination inhibition (HI) assay, a sensitive measles plaque neutralization assay, and four rubella assays with corresponding sensitivity limits of approximately 15, 10, 7.5, and 5 international units (IU) of rubella antibody/ml respectively. Using the most sensitive assays, seroprevalence was 98.6% for measles antibodies and 93.1% for any rubella antibodies. For persons who received single doses of either combined measles and rubella vaccines or separate single vaccinations at different times, there were no significant differences in seroprevalence using sensitive assays. Of persons who received combined vaccines, 99.3% had antibody against measles compared to 98.4% of single antigen recipients. For rubella, 98.6% of combined vaccine recipients had antibody compared to 95.7% of single antigen recipients. These seroprevalence data indicate the effectiveness of a combined vaccination program and support epidemiologic data indicating virtual elimination of these diseases in Massachusetts schoolchildren.
1982年，在马萨诸塞州对六年级、十年级和十二年级的学童进行了一项全州范围的血清学调查。血清通过标准麻疹血凝抑制（HI）试验、灵敏的麻疹空斑中和试验以及四种风疹试验进行筛查，相应的风疹抗体灵敏度限值分别约为每毫升15、10、7.5和5国际单位（IU）。使用最灵敏的试验，麻疹抗体血清阳性率为98.6%，风疹抗体血清阳性率为93.1%。对于在不同时间接受过一剂麻疹风疹联合疫苗或单独单苗接种的人，使用灵敏试验时血清阳性率无显著差异。在接受联合疫苗的人中，99.3%有麻疹抗体，而单抗原接种者为98.4%。对于风疹，联合疫苗接种者中有98.6%有抗体，而单抗原接种者为95.7%。这些血清阳性率数据表明联合疫苗接种计划的有效性，并支持流行病学数据，表明在马萨诸塞州学童中这些疾病几乎已被消除。
