Stigsby B, Bohlega S, McLean D R, Al-Kawi M Z
Section of Neurophysiology, Department of Neurosciences, King Faisal Specialist Hospital and Research Centre, 11211, Riyadh, Saudi Arabia.
Clin Neurophysiol. 2000 Jul;111(7):1320-9. doi: 10.1016/s1388-2457(00)00312-6.
To compare neurological involvement in Behçet's disease as documented by transcranial magnetic stimulation (TMS) with clinical, neuroradiological, somatosensory (SEP) and auditory evoked potential (BAEP) findings.
Forty-four patients were studied over an 8 year period. Nine patients had follow-up studies done. TMS central motor conduction (CMC) studies to upper and lower limb muscles, brain magnetic resonance imaging (MRI), SEP, and BAEP testing were conducted.
Thirty-nine patients had CMC slowing, decreased amplitude or absent motor evoked potentials (MEP); 5 of these patients were neurologically normal. Concordance of TMS results, clinical deficits, and MRI findings occurred in 36 of the 39 patients. SEP and BAEP testing proved non-complementary to MEP. Generally, follow-up studies revealed faster CMC and higher MEP amplitude. However, in two patients the CMC time to one target muscle became prolonged with diminished MEP amplitude over a period of 1.5-3 years.
TMS can be useful in detecting and quantifying motor tract dysfunction in Behçet's disease and provides functional information complementary to imaging studies. TMS is more sensitive than either SEP or BAEP. Our longitudinal studies suggest that TMS studies may be valuable in monitoring disease activity or therapeutic response.
比较经颅磁刺激（TMS）记录的白塞病神经受累情况与临床、神经放射学、体感诱发电位（SEP）及听觉诱发电位（BAEP）的检查结果。
在8年期间对44例患者进行了研究。其中9例患者进行了随访研究。对上下肢肌肉进行了TMS中枢运动传导（CMC）研究、脑磁共振成像（MRI）、SEP及BAEP检测。
39例患者存在CMC减慢、波幅降低或运动诱发电位（MEP）缺失；其中5例患者神经功能正常。39例患者中有36例TMS结果、临床缺陷及MRI表现具有一致性。SEP和BAEP检测结果对MEP无补充作用。总体而言，随访研究显示CMC加快且MEP波幅升高。然而，有2例患者在1.5至3年期间，某一目标肌肉的CMC时间延长且MEP波幅降低。
TMS有助于检测和量化白塞病运动传导束功能障碍，并提供与影像学研究互补的功能信息。TMS比SEP或BAEP更敏感。我们的纵向研究表明，TMS研究可能对监测疾病活动或治疗反应具有重要价值。
