Almli C R, McMullen N T, Golden G T
Brain Res Bull. 1976 Nov-Dec;1(6):543-52. doi: 10.1016/0361-9230(76)90081-2.
Single-unit recordings were made from lateral hypothalamic area (LHA) neurons of infant (8 through 21 days of age) male and female albino rats. Basal (or spontaneous) firing rates of LHA neurons were recorded for 20 min from rats 8 through 21 days of age, and mean basal firing rates did not differ across ages. Basal firing rates of LHA neurons in infant rats ranged from less than 1 spike/sec up to 27 spikes/sec, with 56% of the basal rates less than 1 spike/sec. Infant rats also received hypertonic saline injections (and control injections) to determine osmosensitivity characteristics of LHA neurons. Across ages, 56%--88% of LHA neurons were osmosensitive, with the highest percentages of osmosensitive units found in rats 14--21 days of age. Infant rats showed LHA unit electrophysiological characteristics that were quite similar to those obtained from LHA neurons in adult rats with respect to basal firing rates and osmosensitivity, however, LHA neuron activity in infants was not modulated by sensory stimuli as is frequently reported for adults. The results are discussed in terms of functional development of the LHA.
对幼年（8至21日龄）雄性和雌性白化大鼠的下丘脑外侧区（LHA）神经元进行了单单位记录。记录了8至21日龄大鼠LHA神经元的基础（或自发）放电率20分钟，各年龄段的平均基础放电率没有差异。幼年大鼠LHA神经元的基础放电率范围从每秒不到1个峰电位到每秒27个峰电位，其中56%的基础放电率低于每秒1个峰电位。幼年大鼠还接受了高渗盐水注射（以及对照注射），以确定LHA神经元的渗透压敏感性特征。在所有年龄段中，56% - 88%的LHA神经元具有渗透压敏感性，其中在14 - 21日龄的大鼠中发现的渗透压敏感单位百分比最高。幼年大鼠的LHA单位电生理特征在基础放电率和渗透压敏感性方面与成年大鼠LHA神经元的特征非常相似，然而，婴儿的LHA神经元活动不像经常报道的成年大鼠那样受到感觉刺激的调节。根据LHA的功能发育对结果进行了讨论。
