Almli C R, McMullen N T
Brain Res Bull. 1979 Nov-Dec;4(6):773-81. doi: 10.1016/0361-9230(79)90011-x.
Extracellular single unit recordings were made from units within the lateral preoptic area (LPO) of infant rats from 1 day of age through 31 days of age (postweaning). The rats were anesthetized with dial-urethane and basal (spontaneous) spike rates were recorded for 10--20 min. The rats also received pain-arousal stimulation (tail-pinch and sc injection of formalin solution), and osmotic stimulation (sc or ip injection of hyperosmotic NaCl or sucrose solutions). LPO units were spontaneously active in neonatal rats; however, basal spike rates increased during development. Also increasing during development was the percentage of LPO units which displayed alteration of spike rate in response to hyperosmotic injections (osmosensitive). However, LPO units were found that were responsive to severe pain-arousal stimulation at all ages tested. The developmental changes in LPO unit activity characteristics paralleled the morphological development of LPO neurons and the development of osmotically induced drinking behaviors.
从出生1天到31天（断奶后）的幼鼠外侧视前区（LPO）内的神经元进行细胞外单单位记录。用二乙烯脲麻醉大鼠，并记录10 - 20分钟的基础（自发）放电率。大鼠还接受疼痛唤醒刺激（夹尾和皮下注射福尔马林溶液）和渗透压刺激（皮下或腹腔注射高渗氯化钠或蔗糖溶液）。LPO神经元在新生大鼠中自发活动；然而，基础放电率在发育过程中增加。对高渗注射有反应（渗透压敏感）的LPO神经元的百分比在发育过程中也增加。然而，在所有测试年龄都发现LPO神经元对严重疼痛唤醒刺激有反应。LPO神经元活动特征的发育变化与LPO神经元的形态发育以及渗透压诱导的饮水行为的发育平行。
