Coffey J C, Johnsonbaugh R E
Steroids. 1979 Apr;33(4):427-34. doi: 10.1016/0039-128x(79)90016-3.
Homogenates prepared from fetal rhesus monkey testes were incubated with progesterone, 4-androstene-3,17-dione, testosterone and 17 beta-hydroxy-5 alpha-androstan-3-one. The major progesterone metabolite was 17-hydroxy-4-pregnene-3,20-dione. Testosterone also accumulated in the progesterone incubations. 4-Androstene-3,17-dione was converted chiefly to testosterone. Testosterone was not actively metabolized by the fetal monkey testis. 17 beta-Hydroxy-5 alpha-androstan-3-one was actively converted primarily to 5 alpha-androstane-3 beta,17 beta-diol.
用恒河猴胎儿睾丸制备的匀浆与孕酮、4-雄烯-3,17-二酮、睾酮和17β-羟基-5α-雄甾烷-3-酮一起孵育。主要的孕酮代谢产物是17-羟基-4-孕烯-3,20-二酮。睾酮也在孕酮孵育物中积累。4-雄烯-3,17-二酮主要转化为睾酮。胎儿猴睾丸不活跃代谢睾酮。17β-羟基-5α-雄甾烷-3-酮主要被活跃地转化为5α-雄甾烷-3β,17β-二醇。
