Wada H, Oshima T, Fukuda I, Karasawa F, Sato T
Department of Anesthesiology, National Defense Medical College, Tokorozawa.
Masui. 2000 Jun;49(6):611-4.
Continuous intravenous administration of Diprivan (1% propofol emulsion, P) is usually carried out using a syringe-pump or an infusion-pump to adjust the infusion rate. We assessed the accuracy of the infusion dose of P and the serum concentration of propofol by manual controls during anesthesia. Twenty eight patients, anesthetized with oxygen, P and vecuronium in combination with fentanyl and epidural block were randomly assigned to either of the following groups; P was administered using the drip-infusion (the group D, n = 14) or a syringe-pump (the group S; n = 14). In the group D, we used the drip-rate table to calculate the dose of P. We assessed (1) the total infusion volume of P which was calculated from the infusion rate and duration (Vc), and also measured by a calibrated cylinder (Vm) in the group D (n = 14) and group S (n = 14), and (2) the serum propofol concentrations 40 min after infusion of P (6 mg.kg-1.hr-1) were assayed using the HPLC. The Vc was well correlated with the Vm in the group D (r = 0.976) and in the group S (r = 0.974). Mean serum propofol concentrations of the group D and S were 2.50 +/- 0.57 and 2.35 +/- 0.62 micrograms.ml-1, respectively. The results suggest that the drip-infusion technique of P may be substituted safely by the syringe-pump for continuous total intravenous anesthesia.
丙泊酚乳剂（1%丙泊酚乳剂，P）的持续静脉给药通常使用注射器泵或输液泵来调节输注速率。我们评估了麻醉期间手动控制时P的输注剂量准确性和丙泊酚血清浓度。28例患者，采用氧气、P、维库溴铵联合芬太尼及硬膜外阻滞麻醉，随机分为以下两组；P采用滴注法给药（D组，n = 14）或注射器泵给药（S组；n = 14）。在D组，我们使用滴注速率表来计算P的剂量。我们评估了（1）D组（n = 14）和S组（n = 14）中根据输注速率和持续时间计算的P总输注量（Vc），以及用校准量筒测量的量（Vm），（2）输注P（6mg·kg-1·hr-1）40分钟后的血清丙泊酚浓度，采用高效液相色谱法测定。D组中Vc与Vm相关性良好（r = 0.976），S组中（r = 0.974）。D组和S组的平均血清丙泊酚浓度分别为2.50±0.57和2.35±0.62微克·毫升-1。结果表明，P的滴注技术可被注射器泵安全替代用于持续全静脉麻醉。
