Koldovský O
Department of Pediatrics, University of Arizona, College of Medicine, Tucson 85724, USA.
J Mammary Gland Biol Neoplasia. 1996 Jul;1(3):317-23. doi: 10.1007/BF02018084.
This article reviews the presence and potential physiological significance of hormones and hormonally active substances (including growth factors) in human milk. Human milk has been found to contain several nonpeptide hormones and many peptide hormones and growth factors. In contrast to human breast milk, infant formulae lack some hormonally active peptides. There is little data concerning the effects of these agents on human neonates. Studies in immature experimental animals showing effects of orogastically administered hormones are summarized. The problems of supplementation of infant formula are discussed. Since hormones are present in the milk as a "cocktail" of potentially agonistic and antagonistic substances, one question is whether supplementation with a single agent would disturb this balance.
本文综述了人乳中激素及激素活性物质(包括生长因子)的存在情况及其潜在的生理意义。已发现人乳中含有多种非肽类激素、许多肽类激素和生长因子。与母乳相比,婴儿配方奶粉缺乏一些具有激素活性的肽。关于这些物质对人类新生儿影响的数据很少。本文总结了在未成熟实验动物中进行的经口给予激素的研究。讨论了婴儿配方奶粉补充剂的问题。由于激素以潜在的激动剂和拮抗剂“鸡尾酒”的形式存在于乳汁中,一个问题是补充单一物质是否会扰乱这种平衡。