Dvorák B, Holubec H, LeBouton A V, Wilson J M, Koldovský O
Department of Pediatrics, University of Arizona, College of Medicine, Tucson 85724.
FEBS Lett. 1994 Oct 3;352(3):291-5. doi: 10.1016/0014-5793(94)00942-2.
The expression of epidermal growth factor (EGF) and transforming growth factor-alpha (TGF-alpha) mRNA in the small intestine of suckling and adult rats was examined by in situ hybridization. EGF mRNA was found mainly in the intestinal crypts in adult rats. Adult rats also exhibited a considerably stronger signal for EGF mRNA in comparison to suckling rats, where the signal was very low or absent. In contrast to EGF, very strong expression of TGF-alpha mRNA was observed in the small intestine of both adult and suckling rats. These data suggest the differences between the expression of EGF and TGF-alpha in the developing small intestine.
通过原位杂交检测了哺乳期和成年大鼠小肠中表皮生长因子（EGF）和转化生长因子-α（TGF-α）mRNA的表达。EGF mRNA主要在成年大鼠的肠隐窝中发现。与哺乳期大鼠相比，成年大鼠的EGF mRNA信号也明显更强，哺乳期大鼠的信号非常低或不存在。与EGF相反，在成年和哺乳期大鼠的小肠中均观察到TGF-α mRNA的非常强的表达。这些数据表明发育中小肠中EGF和TGF-α表达的差异。
