Milano A, Codecasa R, De Carlo M, Nardi C, Tartarini G, Verunelli F, Bortolotti U
Cardio Thoracic Department, University of Pisa Medical School, Italy.
J Heart Valve Dis. 2000 May;9(3):321-6.
Mitral valve repair (MVR) is the treatment of choice in patients with degenerative valve disease. However, controversy persists as to whether mitral valve annuloplasty should always be included as part of the reconstructive procedure.
The records of 62 consecutive patients undergoing MVR for degenerative disease between January 1994 and December 1996 were reviewed. Four different annuloplasty techniques were associated with various MVR procedures: local posterior annuloplasty (group 1, n = 10), rigid Carpentier ring (group 2, n = 20), Duran ring (group 3, n = 17), and posterior annular plication with autologous pericardium (group 4, n = 15). The four patient groups were similar in terms of preoperative clinical and echocardiographic characteristics. Serial clinical and echocardiographic follow up was performed to assess functional status and stability of repair.
There were no early or late deaths. Mean follow up in the entire patient series was 31 +/- 12 months. One patient in group 2 required reoperation 14 months after MVR. In all groups there was a significant improvement in NYHA functional class (from 2.7 +/- 0.6 to 0.9 +/- 0.5, p <0.001), with a reduction of left ventricular end-diastolic and end-systolic volumes (154 +/- 50 ml to 105 +/- 33 ml, p <0.001; and 64 +/- 23 ml to 52 +/- 22 ml, p <0.001). In patients of groups 2, 3 and 4, residual mitral incompetence at follow up (0.8 +/- 0.9 in group 2, 0.8 +/- 0.7 in group 3, and 0.2 +/- 0.6 in group 4) was not significantly different from discharge. However, in group 1, a higher degree of residual mitral regurgitation was present at discharge (0.9 +/- 0.6) with a trend to progress at follow up (1.6 +/- 0.5).
In patients with degenerative mitral valve disease, MVR provides clinical and functional improvement. Techniques of stabilization of the entire posterior mitral annulus achieve better early and medium-term results, and should be always considered as part of MVR. Autologous pericardium appears to be an excellent annuloplasty material, though its apparent superiority over synthetic rings must be confirmed at longer follow up.
二尖瓣修复术(MVR)是退行性瓣膜病患者的首选治疗方法。然而,对于二尖瓣瓣环成形术是否应始终作为重建手术的一部分,仍存在争议。
回顾了1994年1月至1996年12月期间连续62例因退行性疾病接受MVR的患者的记录。四种不同的瓣环成形术技术与各种MVR手术相关:局部后瓣环成形术(第1组,n = 10)、刚性Carpentier环(第2组,n = 20)、Duran环(第3组,n = 17)和自体心包后瓣环折叠术(第4组,n = 15)。这四个患者组在术前临床和超声心动图特征方面相似。进行了系列临床和超声心动图随访,以评估功能状态和修复的稳定性。
无早期或晚期死亡病例。整个患者系列的平均随访时间为31±12个月。第2组中有1例患者在MVR后14个月需要再次手术。所有组的纽约心脏协会(NYHA)功能分级均有显著改善(从2.7±0.6降至0.9±0.5,p<0.001),左心室舒张末期和收缩末期容积减小(从154±50 ml降至105±33 ml,p<0.001;从64±23 ml降至52±22 ml,p<0.001)。在第2、3和4组患者中,随访时的二尖瓣反流残余量(第2组为0.8±0.9,第3组为0.8±0.7,第4组为0.2±0.6)与出院时无显著差异。然而,在第1组中,出院时二尖瓣反流残余程度较高(0.9±0.6),且随访时有进展趋势(1.6±0.5)。
对于退行性二尖瓣疾病患者,MVR可改善临床和功能。稳定整个二尖瓣后瓣环的技术可取得更好的早期和中期效果,应始终被视为MVR的一部分。自体心包似乎是一种出色的瓣环成形术材料,不过其相对于合成环的明显优势必须通过更长时间的随访来证实。