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比较二尖瓣修复术中的柔性、开放式与半刚性、封闭式瓣环成形环。

Comparison of flexible, open with semi-rigid, closed annuloplasty-rings for mitral valve repair.

机构信息

Department of Cardiac Surgery, Kerckhoff-Heart Center Bad Nauheim, Campus of the University Hospital Giessen, Justus-Liebig Universiy Giessen, Benekestraße 2-8, 61231, Bad Nauheim, Germany.

Institute for Pharmacology and Preventive Medicine, Cloppenburg, Germany.

出版信息

J Cardiothorac Surg. 2021 Mar 20;16(1):35. doi: 10.1186/s13019-021-01405-1.

Abstract

BACKGROUND

Mitral regurgitation is a frequent valvular disease, with an increasing prevalence. We analysed the long-term outcomes of mitral valve repair procedures conducted over the last 10 years in our clinic using almost exclusively two different annuloplasty ring types.

METHODS

A single-centre, retrospective analysis of mitral valve surgeries conducted between January 2005 and December 2015 for patients undergoing first-line mitral valve repair with either open (Cosgrove) or closed (CE Physio / Physio II) annuloplasty (OA or CA, respectively) rings.

RESULTS

In total, 1120 patient documentations were available of which 528 underwent OA and 592 patients CA. The median age of patients was 64.0 years and 41.1% were female. The majority of these patients underwent the procedure because of degenerative valve disease. Rates of successful repair were about 90%, 72 h procedural mortality was 0.6% and the rate of re-intervention was 0.6% within the first 30 days. Functional (mitral regurgitation, left ventricular ejection fraction, left ventricular end-diastolic and systolic diameter and New York Heart Association class) as well as hard outcomes were comparable. 77.7 and 74.4% of patients were alive at the 10-year follow-up in the OA and CA groups, respectively. Upon multivariable adjustment, the hazard ratio was 0.926 (95% CI: 0.642-1.3135; p = 0.681).

CONCLUSIONS

The functional outcome and survival rates up to 10 years after mitral valve repair were comparable using open and closed annuloplasty rings. Whether this means these rings are interchangeable or a carefully selection of the best-for-the-patient devices will be subject of future investigations.

摘要

背景

二尖瓣反流是一种常见的瓣膜疾病,其患病率呈上升趋势。我们分析了过去 10 年在我们诊所进行的二尖瓣修复手术的长期结果,这些手术几乎完全使用两种不同的瓣环成形环类型。

方法

对 2005 年 1 月至 2015 年 12 月期间接受一线二尖瓣修复术的患者进行了单中心回顾性分析,这些患者分别接受了开放式(Cosgrove)或闭式(CE Physio / Physio II)瓣环成形术(OA 或 CA)。

结果

共有 1120 例患者的病历可供查阅,其中 528 例接受了 OA 手术,592 例接受了 CA 手术。患者的中位年龄为 64.0 岁,41.1%为女性。这些患者中大多数因退行性瓣膜疾病接受了该手术。修复成功率约为 90%,72 小时手术死亡率为 0.6%,30 天内再次介入率为 0.6%。功能(二尖瓣反流、左心室射血分数、左心室舒张末期和收缩末期直径以及纽约心脏协会分级)和硬终点均相似。OA 和 CA 组患者分别在 10 年随访时的存活率为 77.7%和 74.4%。多变量调整后,风险比为 0.926(95%CI:0.642-1.3135;p=0.681)。

结论

使用开放式和闭式瓣环成形环修复二尖瓣后,功能结果和 10 年生存率相当。这是否意味着这些环可以互换,或者为患者选择最佳设备将是未来研究的主题。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9141/7981851/24946bacfa15/13019_2021_1405_Fig1_HTML.jpg

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