Knuth A, Pribilla W, Marti H R, Winterhalter K H
Acta Haematol. 1979;61(3):121-4. doi: 10.1159/000207643.
A new alpha chain abnormal hemoglobin variant was found in a Turkish patient with a mild Heinz body hemolytic anemia and splenomegaly. The substitution alpha 86 Leu leads to Arg, which is next to the heme binding proximal histidine, is responsible for a marked instability of the molecule. The oxygen affinity of the erythrocytes was found to be slightly decreased.
