McMahon F G
JAMA. 1975 Jan 13;231(2):155-8.
In a double-blind evaluation, the efficacy of a combination of methyldopa with hydrochlorothiazide was compared with that of its components, methyldopa and hydrochlorothiazide. The combination was found to be more efficacious than either of its components. It reduced the arithmetic mean of the pressures of all patients from 170/116 to 133/95 mm Hg in four weeks. Despite the greater effect of the combination, side effects were mild.
在一项双盲评估中，将甲基多巴与氢氯噻嗪的组合疗效与其成分甲基多巴和氢氯噻嗪的疗效进行了比较。结果发现，该组合比其任何一种成分都更有效。在四周内，它将所有患者的血压算术平均值从170/116降至133/95毫米汞柱。尽管该组合的效果更佳，但副作用较轻。
