荷兰牛羊体内肝片吸虫对三氯苯达唑的耐药性
Resistance of Fasciola hepatica against triclabendazole in cattle and sheep in The netherlands.
作者信息
Moll L, Gaasenbeek C P, Vellema P, Borgsteede F H
机构信息
Animal Health Service, Location Drachten, P.O. Box 361, 9200 AJ, Drachten, Netherlands.
出版信息
Vet Parasitol. 2000 Jul 24;91(1-2):153-8. doi: 10.1016/s0304-4017(00)00267-3.
In the winter of 1998/1999, sheep on a farm in the province of North Holland, The Netherlands, died from subacute and chronic liver fluke disease despite four previous treatments with triclabendazole (TCBZ). Faecal examinations of sheep and cattle on the farm showed high number of liver fluke eggs. In a randomised clinical trial, the fluke egg output was monitored weekly for 3 weeks in sheep which were treated with TCBZ or with closantel; in dairy cows treated with TCBZ or with clorsulon; and in heifers treated with TCBZ or clorsulon. The results showed a significant reduction of 99.7, 98.1 and 99.2%, respectively, in fluke egg output at 21 days in all non-TCBZ treated animals. TCBZ treatment produced percentage decreases of 15.3, 4.3 and 36.6%, respectively. These results are highly indicative of the presence of TCBZ-resistant Fasciola hepatica in sheep and cattle on this farm.
1998/1999年冬季，荷兰北荷兰省一个农场的绵羊尽管此前已用三氯苯达唑（TCBZ）进行了四次治疗，但仍死于亚急性和慢性肝吸虫病。该农场绵羊和牛的粪便检查显示肝吸虫卵数量很多。在一项随机临床试验中，对用TCBZ或氯氰碘柳胺治疗的绵羊、用TCBZ或氯舒隆治疗的奶牛以及用TCBZ或氯舒隆治疗的小母牛，每周监测3周的吸虫卵产量。结果显示，在所有未用TCBZ治疗的动物中，21天时吸虫卵产量分别显著降低了99.7%、98.1%和99.2%。用TCBZ治疗的动物，吸虫卵产量分别降低了15.3%、4.3%和36.6%。这些结果高度表明该农场的绵羊和牛体内存在对TCBZ耐药的肝片吸虫。
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