Uusitupa M, Louheranta A, Lindström J, Valle T, Sundvall J, Eriksson J, Tuomilehto J
Department of Clinical Nutrition University of Kuopio, Finland.
Br J Nutr. 2000 Mar;83 Suppl 1:S137-42. doi: 10.1017/s0007114500001070.
The aim of the Finnish Diabetes Prevention Study is to assess the efficacy of an intensive diet-exercise programme in preventing or delaying type 2 diabetes in individuals with impaired glucose tolerance (IGT) and to evaluate the effect of the programme on the risk factors of atherosclerotic vascular diseases and the incidence of cardiovascular events. In this ongoing study, a total of 523 overweight subjects with IGT based on two oral glucose tolerance tests were randomized to either an intervention group or a control group. The main measure in the intervention group is individual dietary advice aimed at reducing weight and intake of saturated fat and increasing intake of dietary fibre. The intervention subjects are individually guided to increase their level of physical activity. The control group receives general information about the benefits of weight reduction, physical activity and healthy diet in the prevention of diabetes. A pilot study began in 1993, and recruitment ended in 1998. By the end of April 1999 there were 65 new cases of diabetes, 34 drop-outs and one death. The weight reduction was greater (-4.6 kg) at 1 year in the intervention group (n = 152) than in the control group (n = 143, -0.9 kg, P < 0.0001), and this difference was sustained in the second year of follow-up. At 1 year 43.4% and at 2 years 41.8% of the intervention subjects had achieved a weight reduction of at least 5 kg, while the corresponding figures for the control subjects were 14.0 and 12.0% (P < 0.001 between the groups). At 1 year the intervention group showed significantly greater reductions in 2 h glucose, fasting and 2 h insulin, systolic and diastolic blood pressure, and serum triglycerides. Most of the beneficial changes in cardiovascular risk factors were sustained for 2 years. These interim results of the ongoing Finnish Diabetes Prevention Study demonstrate the efficacy and feasibility of the lifestyle intervention programme.
芬兰糖尿病预防研究的目的是评估强化饮食 - 运动计划在预防或延缓糖耐量受损（IGT）个体患2型糖尿病方面的疗效，并评估该计划对动脉粥样硬化性血管疾病危险因素及心血管事件发生率的影响。在这项正在进行的研究中，基于两次口服葡萄糖耐量试验，共有523名超重的IGT受试者被随机分为干预组或对照组。干预组的主要措施是针对减轻体重、减少饱和脂肪摄入以及增加膳食纤维摄入的个体化饮食建议。干预对象会得到个体化指导以提高其身体活动水平。对照组则接受关于减轻体重、身体活动和健康饮食对预防糖尿病有益之处的一般信息。一项试点研究于1993年开始，招募工作于1998年结束。到1999年4月底，有65例新的糖尿病病例、34例退出研究和1例死亡。干预组（n = 152）在1年时的体重减轻幅度（-4.6 kg）大于对照组（n = 143，-0.9 kg，P < 0.0001），且这种差异在随访的第二年得以持续。在1年时，43.4%的干预对象体重减轻至少5 kg，2年时这一比例为41.8%，而对照组相应的比例分别为14.0%和12.0%（两组间P < 0.001）。在1年时，干预组在2小时血糖、空腹及2小时胰岛素、收缩压和舒张压以及血清甘油三酯方面的降低幅度显著更大。心血管危险因素的大多数有益变化持续了2年。芬兰糖尿病预防研究的这些中期结果证明了生活方式干预计划的有效性和可行性。
