Lewis U J, Sinha Y N, Lewis G P
Neuroscience Institute, University of California Santa Barbara, 93117, USA.
Endocr J. 2000 Mar;47 Suppl:S1-8. doi: 10.1507/endocrj.47.supplmarch_s1.
This review will summarize the properties of five variant forms of human growth hormone: a disulfide dimer, a glycosylated form, 20 kD-hGH, and two peptides made up of portions of 22 kD-hGH. The two pituitary peptides (hGH(1-43) and hGH(44-191)) have, respectively, insulin-potentiating and anti-insulin properties. Both have been detected in serum. The shorter peptide may prove to be useful in decreasing the amount of exogenous insulin required by diabetics. The larger, strongly anti-insulin peptide, may be involved in diabetic retinopathy. We believe that this peptide is the long sought after diabetogenic substance of the pituitary gland.
一种二硫键二聚体、一种糖基化形式、20kD-人生长激素，以及由22kD-人生长激素部分组成的两种肽。两种垂体肽（hGH(1-43)和hGH(44-191)）分别具有增强胰岛素作用和抗胰岛素特性。二者均在血清中被检测到。较短的肽可能被证明有助于减少糖尿病患者所需的外源性胰岛素量。较大的、具有强烈抗胰岛素作用的肽可能与糖尿病视网膜病变有关。我们认为这种肽就是长期以来一直在寻找的垂体致糖尿病物质。
