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Molecular heterogeneity of human GH: from basic research to clinical implications.

作者信息

Boguszewski C L

机构信息

Service of Endocrinology and Metabolism, Clinical Hospital, Federal University of Paraná (SEMPR), Department of Internal Medicine, Curitiba, Brazil.

出版信息

J Endocrinol Invest. 2003 Mar;26(3):274-88. doi: 10.1007/BF03345170.

DOI:10.1007/BF03345170
PMID:12809181
Abstract
摘要

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Molecular heterogeneity of human GH: from basic research to clinical implications.人生长激素的分子异质性：从基础研究到临床意义
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2
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Identification of human pituitary growth hormone variants by mass spectrometry.
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N-glycosylated variants of growth hormone in human pituitary extracts.人垂体提取物中生长激素的N-糖基化变体。
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Structure and properties of members of the hGH family: a review.人生长激素家族成员的结构与特性：综述
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Growth hormone in sport: beyond Beijing 2008.体育领域中的生长激素：后北京2008时代
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Interpreting growth hormone and IGF-I results using modern assays and reference ranges for the monitoring of treatment effectiveness in acromegaly.使用现代检测方法和参考范围解读生长激素和 IGF-1 结果，以监测肢端肥大症的治疗效果。
Front Endocrinol (Lausanne). 2023 Oct 25;14:1266339. doi: 10.3389/fendo.2023.1266339. eCollection 2023.
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Pathol Int. 2020 Jun;70(6):340-347. doi: 10.1111/pin.12915. Epub 2020 Feb 21.
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本文引用的文献

1
Growth Hormone What is it and what does it do?生长激素是什么，它有什么作用？
Trends Endocrinol Metab. 1992 May-Jun;3(4):117-21. doi: 10.1016/1043-2760(92)90099-m.
2
THE RELATION BETWEEN THE GROWTH AND DIABETOGENIC EFFECTS OF THE SO-CALLED GROWTH HORMONE OF THE ANTERIOR PITUITARY.垂体前叶所谓生长激素的生长作用与致糖尿病作用之间的关系
Diabetes. 1964 Nov-Dec;13:651-5. doi: 10.2337/diab.13.6.651.
3
Long-term treatment of acromegaly with pegvisomant, a growth hormone receptor antagonist.使用生长激素受体拮抗剂培维索孟长期治疗肢端肥大症。
人类垂体腺瘤蛋白质组学：新进展与展望
Front Endocrinol (Lausanne). 2016 May 31;7:54. doi: 10.3389/fendo.2016.00054. eCollection 2016.
4
Discordance between growth hormone and insulin-like growth factor-1 after pituitary surgery for acromegaly: a stepwise approach and management.肢端肥大症垂体手术后生长激素与胰岛素样生长因子-1之间的不一致：一种逐步处理方法及管理
Pituitary. 2015 Feb;18(1):48-59. doi: 10.1007/s11102-014-0556-y.
5
Comparison of two immunoassays in the determination of IGF-I levels and its correlation with oral glucose tolerance test (OGTT) and with clinical symptoms in acromegalic patients.比较两种免疫分析法在测定 IGF-I 水平及其与口服葡萄糖耐量试验（OGTT）和肢端肥大症患者临床症状的相关性。
Pituitary. 2012 Dec;15(4):466-71. doi: 10.1007/s11102-011-0351-y.
6
O-Glycosylated 24 kDa human growth hormone has a mucin-like biantennary disialylated tetrasaccharide attached at Thr-60.O-糖基化的24 kDa人生长激素在苏氨酸-60处连接有一个粘蛋白样的双触角二唾液酸化四糖。
Proteomics. 2009 Jul;9(13):3474-88. doi: 10.1002/pmic.200800989.
7
Growth hormone during development.发育过程中的生长激素。
Rev Endocr Metab Disord. 2005 Aug;6(3):173-82. doi: 10.1007/s11154-005-3048-6.
8
Extraordinarily stable disulfide-linked homodimer of human growth hormone.人生长激素异常稳定的二硫键连接的同型二聚体。
Protein Sci. 2005 Apr;14(4):902-13. doi: 10.1110/ps.041048805. Epub 2005 Mar 1.
Lancet. 2001 Nov 24;358(9295):1754-9. doi: 10.1016/s0140-6736(01)06844-1.
4
Relationships between placental GH concentration and maternal smoking, newborn gender, and maternal leptin: possible implications for birth weight.胎盘生长激素浓度与孕妇吸烟、新生儿性别及孕妇瘦素之间的关系：对出生体重的可能影响。
J Clin Endocrinol Metab. 2001 Oct;86(10):4854-9. doi: 10.1210/jcem.86.10.7971.
5
Clinical use of a growth hormone receptor antagonist in the treatment of acromegaly.生长激素受体拮抗剂在肢端肥大症治疗中的临床应用。
Trends Endocrinol Metab. 2001 Nov;12(9):408-13. doi: 10.1016/s1043-2760(01)00461-1.
6
Doping with growth hormone.使用生长激素兴奋剂。
J Pediatr Endocrinol Metab. 2001 Sep-Oct;14(8):1077-83. doi: 10.1515/jpem-2001-0802.
7
Insulin, growth hormone and sport.
J Endocrinol. 2001 Jul;170(1):13-25. doi: 10.1677/joe.0.1700013.
8
Growth hormone binding protein 2001.生长激素结合蛋白2001
J Pediatr Endocrinol Metab. 2001 Apr;14(4):355-75. doi: 10.1515/jpem.2001.14.4.355.
9
Ghrelin: discovery of the natural endogenous ligand for the growth hormone secretagogue receptor.胃饥饿素：生长激素促分泌素受体天然内源性配体的发现。
Trends Endocrinol Metab. 2001 Apr;12(3):118-22. doi: 10.1016/s1043-2760(00)00362-3.
10
Changes in non-22-kilodalton (kDa) isoforms of growth hormone (GH) after administration of 22-kDa recombinant human GH in trained adult males.在训练有素的成年男性中给予22千道尔顿重组人生长激素（GH）后，生长激素（GH）非22千道尔顿（kDa）异构体的变化。
J Clin Endocrinol Metab. 2001 Apr;86(4):1731-7. doi: 10.1210/jcem.86.4.7379.