Hunziker J, Wronski T J, Miller S C
Department of Radiology, School of Medicine, University of Utah, Salt Lake City 84108-1218, USA.
J Dent Res. 2000 Jun;79(6):1431-8. doi: 10.1177/00220345000790061301.
Anti-resorptive agents--including estrogen (E), calcitonin (CT), and bisphosphonates--are established in the treatment of osteoporosis. Intermittent administration of parathyroid hormone (PTH) stimulates bone formation and is a possible therapeutic agent for the restoration of bone mass. The purpose was to determine the effects of the anti-resorptive agents alone and in combination with intermittent PTH on bone formation in the mandible and a long bone in the aged ovariectomized (Ovx) rat. Female rats were ovariectomized or sham-operated. One year later, groups of Ovx rats were treated with E, CT, or the bisphosphonate, Risedronate (NE). Additional groups of Ovx rats were treated with each of these agents in combination with human PTH for 10 weeks. Estrogen treatment suppressed most indices of bone formation in the humerus and mandible, while NE decreased some indices of formation at the endocortical and endosteal surfaces of the mandible and humerus. Increased double-labeled surface and mineral apposition rates were observed only on the mandibular endosteal surfaces following CT treatment. When the anti-resorptive agents were combined with intermittent PTH, most indices of bone formation at all skeletal sites were substantially greater than those of the untreated Ovx controls as well as the E-, CT-, and NE-treated groups, respectively. These results provide additional evidence that established and emerging therapies for osteoporosis affect osseous tissues in the oral cavity, and this may influence the progression of diseases and/or aging changes at this site.
抗骨吸收药物——包括雌激素（E）、降钙素（CT）和双膦酸盐——已被用于骨质疏松症的治疗。间歇性给予甲状旁腺激素（PTH）可刺激骨形成，是恢复骨量的一种可能的治疗药物。目的是确定单独使用抗骨吸收药物以及与间歇性PTH联合使用对老年去卵巢（Ovx）大鼠下颌骨和长骨骨形成的影响。雌性大鼠接受去卵巢手术或假手术。一年后，对去卵巢大鼠组分别给予E、CT或双膦酸盐利塞膦酸钠（NE）治疗。另外几组去卵巢大鼠将这些药物与人类PTH联合使用10周。雌激素治疗抑制了肱骨和下颌骨的大多数骨形成指标，而NE降低了下颌骨和肱骨内皮质和骨内膜表面的一些形成指标。CT治疗后仅在下颌骨骨内膜表面观察到双标记表面和矿物质沉积率增加。当抗骨吸收药物与间歇性PTH联合使用时，所有骨骼部位的大多数骨形成指标分别显著高于未治疗的去卵巢对照组以及E、CT和NE治疗组。这些结果提供了更多证据，表明已有的和新出现的骨质疏松症治疗方法会影响口腔内的骨组织，这可能会影响该部位疾病的进展和/或衰老变化。
