Prabha S P, Rajamohan T
Department of Biochemistry, University of Kerala, Trivandrum, India.
Plant Foods Hum Nutr. 1998;53(1):83-92. doi: 10.1023/a:1008024727534.
The effect of inclusion of cashew globulin to a casein diet on lipid metabolism was studied in rats fed diets with two levels of cashew globulin meal. Inclusion of cashew globulin to a casein diet produced lower levels of total cholesterol, triacylglycerol and phospholipids in the serum and tissues and lower levels of serum lipoprotein cholesterol. There was decreased cholesterogenesis in the liver as evidenced by decreased activity of HMG CoA reductase and decreased release of lipoproteins into circulation. Rats fed cashew globulin along with casein also showed higher activity of LPL in the heart and adipose tissue and higher activity of LCAT. Increased hepatic diversion of cholesterol to bile acid synthesis and increased excretion of bile acids and sterols were also observed in these groups. Activity of glucose-6-phosphate dehydrogenase and malic enzyme was decreased in rats fed cashew globulin along with casein. This study demonstrates that cashew globulins included in the diet of rats are able to alter lipid metabolism which results in lower levels of lipid parameters in the serum and tissues.
在以两种水平的腰果球蛋白粉喂养的大鼠中，研究了在酪蛋白饮食中添加腰果球蛋白对脂质代谢的影响。在酪蛋白饮食中添加腰果球蛋白会使血清和组织中的总胆固醇、三酰甘油和磷脂水平降低，血清脂蛋白胆固醇水平也降低。肝脏中胆固醇合成减少，这表现为HMG CoA还原酶活性降低以及脂蛋白释放到循环中的量减少。同时喂食腰果球蛋白和酪蛋白的大鼠在心脏和脂肪组织中也表现出较高的脂蛋白脂肪酶（LPL）活性以及较高的卵磷脂胆固醇酰基转移酶（LCAT）活性。在这些组中还观察到肝脏将胆固醇更多地用于胆汁酸合成，胆汁酸和固醇的排泄增加。同时喂食腰果球蛋白和酪蛋白的大鼠中，葡萄糖-6-磷酸脱氢酶和苹果酸酶的活性降低。这项研究表明，大鼠饮食中包含的腰果球蛋白能够改变脂质代谢，从而导致血清和组织中的脂质参数水平降低。
