行为、神经营养因子表达与新生神经元存活之间的关系。
A relationship between behavior, neurotrophin expression, and new neuron survival.
作者信息
Li X C, Jarvis E D, Alvarez-Borda B, Lim D A, Nottebohm F
机构信息
The Rockefeller University, 1230 York Avenue, New York, NY 10021; and Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA.
出版信息
Proc Natl Acad Sci U S A. 2000 Jul 18;97(15):8584-9. doi: 10.1073/pnas.140222497.
The high vocal center (HVC) controls song production in songbirds and sends a projection to the robust nucleus of the archistriatum (RA) of the descending vocal pathway. HVC receives new neurons in adulthood. Most of the new neurons project to RA and replace other neurons of the same kind. We show here that singing enhances mRNA and protein expression of brain-derived neurotrophic factor (BDNF) in the HVC of adult male canaries, Serinus canaria. The increased BDNF expression is proportional to the number of songs produced per unit time. Singing-induced BDNF expression in HVC occurs mainly in the RA-projecting neurons. Neuronal survival was compared among birds that did or did not sing during days 31-38 after BrdUrd injection. Survival of new HVC neurons is greater in the singing birds than in the nonsinging birds. A positive causal link between pathway use, neurotrophin expression, and new neuron survival may be common among systems that recruit new neurons in adulthood.
高级发声中枢（HVC）控制鸣禽的鸣叫产生，并向发声下行通路的古纹状体粗核（RA）发出投射。成年期HVC会接收新的神经元。大多数新神经元投射到RA并取代其他同类神经元。我们在此表明，歌唱可增强成年雄性金丝雀（Serinus canaria）HVC中脑源性神经营养因子（BDNF）的mRNA和蛋白质表达。BDNF表达的增加与单位时间内产生的歌曲数量成正比。歌唱诱导的HVC中BDNF表达主要发生在投射到RA的神经元中。在注射BrdUrd后第31 - 38天，比较了唱歌和不唱歌鸟类的神经元存活情况。唱歌鸟类中新的HVC神经元存活率高于不唱歌的鸟类。在成年期招募新神经元的系统中，通路使用、神经营养因子表达和新神经元存活之间的正向因果联系可能很常见。
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