Mattar M E, Markello J, Yaffe S J
Pediatrics. 1975 Jan;55(1):101-8.
Evaluation of treatment given at home was studied in children with otitis media who were seen in an outpatient clinic. Full compliance was present in only 5% of the initial 100 patients (Study A). Practical factors limiting their compliance included inadequate dispensing of medication at drug stores, 15%; incorrect therapy schedule, 36%; early termination, 37%; spilled medicine, 7%; therapy shared, 5%. Because of these findings, a plan was implemented (Study B) in which hospital pharmacy personnel gave patient families verbal and written instructions for administering medications that were dispensed, together with a calibrated measuring device and a calendar to record doses taken. Full compliance was raised to 51% in this pilot group (of 33 patients) as compared with 8.5% in 20 concurrent controls who went to neighborhood drug stores. The importance of detailed therapy instructions is stressed. The potential role of the pharmacist in improving compliance is demonstrated.
对在门诊就诊的中耳炎患儿在家接受治疗的情况进行了研究。在最初的100名患者中，完全依从治疗的仅占5%（研究A）。限制他们依从性的实际因素包括药店配药不足，占15%；治疗时间表不正确，占36%；过早终止治疗，占37%；药物洒落，占7%；与他人共用治疗药物，占5%。基于这些发现，实施了一项计划（研究B），即医院药房工作人员向患者家属提供关于所配药物给药的口头和书面说明，同时提供一个校准测量装置和一个记录服药剂量的日历。该试验组（33名患者）的完全依从率提高到了51%，而同时去附近药店购药的20名对照患者的完全依从率为8.5%。强调了详细治疗说明的重要性。证明了药剂师在提高依从性方面的潜在作用。
