Bailey S R, Andrews M J, Elliott J, Cunningham F M
The Royal Veterinary College, Department of Veterinary Basic Sciences, North Mymms, Hertfordshire, United Kingdom.
Inflamm Res. 2000 May;49(5):224-30. doi: 10.1007/s000110050583.
Altered platelet responsiveness has been demonstrated in human atopic dermatitis. This study has compared the in vitro function of platelets from normal ponies and those with the allergic skin disease, sweet itch.
Ponies with a clinical history of sweet itch and normal ponies were used as blood donors.
PAF and ADP-induced platelet aggregation was measured and TxB2 production quantitated at the time of maximal aggregation; 12-HETE was additionally measured in some samples. Agonist-induced release of 3[H]5-HT was also studied.
Although both PAF and ADP caused equine platelet aggregation, only PAF stimulated eicosanoid and 5-HT release. There were no differences between the responses of platelets from allergic and normal ponies to PAF or ADP (analysis of variance).
There is no evidence of altered platelet responsiveness in ponies with sweet itch. The profile of responses to PAF and ADP suggest differential activation of intracellular signalling pathways in equine platelets.
已证实在人类特应性皮炎中血小板反应性发生改变。本研究比较了正常小马和患过敏性皮肤病（甜痒症）小马的血小板体外功能。
有甜痒症临床病史的小马和正常小马作为献血者。
测量PAF和ADP诱导的血小板聚集，并在最大聚集时定量测定TxB2生成量；部分样本还额外测量了12-HETE。还研究了激动剂诱导的3[H]5-HT释放。
虽然PAF和ADP均引起马血小板聚集，但只有PAF刺激类花生酸和5-HT释放。过敏性小马和正常小马的血小板对PAF或ADP的反应无差异（方差分析）。
没有证据表明患甜痒症的小马血小板反应性发生改变。对PAF和ADP的反应特征表明马血小板中细胞内信号通路的激活存在差异。
