Anderson R I, Fazen L E, Buck A A
Am J Trop Med Hyg. 1975 Jan;24(1):58-61.
Guatermalan volunteers with onchocerciasis were given a dose of diethylcarbamazine to learn if this caused migration of microfilariae of Onchocerca volvulus into urine, blood, and sputum. In 5 of the 10 volunteers, the num0ers of microfilariae in the urine increased considerably following the drug. In the same 5, relatively large numbers of microfilariae were observed in the blood and sputum specimens. Response in the remaining 5 was negligible. Four controls given a placebo did not respond. Interestingly, however, 2 control subjects had onchocercal microfilariae in their concentrated blood specimens and 3 control subjects had microfilariae in the sputum. Therefore, we believe that microfilariae, if searched for, may be found in other parts of the patient not normally associated with the infection.
给患有盘尾丝虫病的危地马拉志愿者服用一剂乙胺嗪，以了解这是否会导致盘尾丝虫的微丝蚴迁移到尿液、血液和痰液中。在10名志愿者中，有5人的尿液中微丝蚴数量在用药后大幅增加。在这相同的5人中，血液和痰液标本中观察到相对大量的微丝蚴。其余5人的反应可忽略不计。4名服用安慰剂的对照者没有反应。然而，有趣的是，2名对照者的浓缩血液标本中有盘尾丝虫微丝蚴，3名对照者的痰液中有微丝蚴。因此，我们认为，如果进行搜索，微丝蚴可能在患者通常与感染无关的其他部位被发现。
