Langham M E, Traub Z D, Richardson R
Tropenmed Parasitol. 1978 Jun;29(2):156-62.
Counts of microfilariae in the skin, and histological and electronmicroscopic procedures have been used to analyze the response of onchocerciasis patients to diethylcarbamazine citrate (DEC) given either orally or topically. Oral administration of DRC failed to eliminate all microfilariae. Transepidermal DEC resulted in rapid degeneration of microfilariae, and daily single applications of the drug greatly reduced or apparently eliminated microfilariae from the skin. Following weekly topical applications of a DEC emulsion, effective suppression of O. volvulus microfilariae in patients living in a hyperendemic area was maintained for many months; and the dermal pathology resolved.
已采用皮肤中微丝蚴计数以及组织学和电子显微镜检查方法，分析盘尾丝虫病患者对口服或局部应用枸橼酸乙胺嗪（DEC）的反应。口服DEC未能清除所有微丝蚴。经皮给予DEC导致微丝蚴迅速退化，每天单次应用该药物可使皮肤中的微丝蚴大幅减少或明显清除。每周局部应用DEC乳剂后，在高度流行地区生活的患者中，对旋盘尾丝虫微丝蚴的有效抑制可维持数月；皮肤病理学改变也得到缓解。
