Schöni M H
Universitäts-Kinderklinik, Inselspital Bern.
Ther Umsch. 2000 Jun;57(6):351-4. doi: 10.1024/0040-5930.57.6.351.
Inhibition of carbonic anhydrase in general or specific inhibition of one the different isoenzymes results in a significant metabolic acidosis due to renal bicarbonate loss. The increase of arterial pCO2 stimulates central and peripheral chemoreceptors and enhances ventilation. The inhibition of carbonic anhydrase as a respiratory stimulant is an accepted measure for the prevention of acute mountain sickness, has been used for a restricted number of subjects with sleep-disordered breathing or chronic hypoxaemic lung disease. The few indications and the narrow therapeutic index restrict the use of carbonic anhydrase blockers as stimulants for ventilation.
一般情况下抑制碳酸酐酶或特异性抑制不同的同工酶之一，会因肾碳酸氢盐丢失而导致显著的代谢性酸中毒。动脉血二氧化碳分压升高会刺激中枢和外周化学感受器并增强通气。抑制碳酸酐酶作为一种呼吸兴奋剂，是预防急性高原病的一种公认措施，已用于数量有限的患有睡眠呼吸障碍或慢性低氧性肺病的受试者。适应症少且治疗指数窄限制了碳酸酐酶阻滞剂作为通气兴奋剂的应用。
