Streit A, Berliner A J, Papanayotou C, Sirulnik A, Stern C D
Department of Genetics and Development, Columbia University, New York, New York 10032, USA.
Nature. 2000 Jul 6;406(6791):74-8. doi: 10.1038/35017617.
During neural induction, the 'organizer' of the vertebrate embryo instructs neighbouring ectodermal cells to become nervous system rather than epidermis. This process is generally thought to occur around the mid-gastrula stage of embryogenesis. Here we report the isolation of ERNI, an early response gene to signals from the organizer (Hensen's node). Using ERNI as a marker, we present evidence that neural induction begins before gastrulation--much earlier in development than previously thought. We show that the organizer and some of its precursor cells produce a fibroblast growth factor signal, which can initiate, and is required for, neural induction.
在神经诱导过程中，脊椎动物胚胎的“组织者”指导相邻的外胚层细胞发育成神经系统而非表皮。这一过程通常被认为发生在胚胎发育的原肠胚中期左右。在此，我们报告了ERNI的分离，它是对来自组织者（亨氏结）信号的早期反应基因。以ERNI作为标记，我们提供证据表明神经诱导在原肠胚形成之前就已开始——比之前认为的发育时间要早得多。我们发现组织者及其一些前体细胞产生一种成纤维细胞生长因子信号，该信号能够启动神经诱导，并且是神经诱导所必需的。
