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大肠杆菌烟酰胺单核苷酸腺苷酸转移酶基因的鉴定

Identification of the Escherichia coli nicotinic acid mononucleotide adenylyltransferase gene.

作者信息

Mehl R A, Kinsland C, Begley T P

机构信息

Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, USA.

出版信息

J Bacteriol. 2000 Aug;182(15):4372-4. doi: 10.1128/JB.182.15.4372-4374.2000.

DOI:10.1128/JB.182.15.4372-4374.2000
PMID:10894752
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC101968/
Abstract

The gene (ybeN) coding for nicotinate mononucleotide adenylyltransferase, an NAD(P) biosynthetic enzyme, has been identified and overexpressed in Escherichia coli. This enzyme catalyzes the reversible adenylation of nicotinate mononucleotide and shows product inhibition. The rate of adenylation of nicotinate mononucleotide is at least 20 times faster than the rate of adenylation of nicotinamide mononucleotide.

摘要

编码烟酰胺单核苷酸腺苷酸转移酶（一种NAD(P)生物合成酶）的基因（ybeN）已在大肠杆菌中被鉴定并过表达。该酶催化烟酰胺单核苷酸的可逆腺苷化反应，并表现出产物抑制作用。烟酰胺单核苷酸的腺苷化速率比烟酰胺单核苷酸的腺苷化速率至少快20倍。

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