ORCA3，一种茉莉酸响应型植物初级和次级代谢转录调节因子。
ORCA3, a jasmonate-responsive transcriptional regulator of plant primary and secondary metabolism.
作者信息
van der Fits L, Memelink J
机构信息
Institute of Molecular Plant Sciences, Clusius Laboratory, Leiden University, Wassenaarseweg 64, 2333 AL, Leiden, Netherlands.
出版信息
Science. 2000 Jul 14;289(5477):295-7. doi: 10.1126/science.289.5477.295.
Biosynthesis of many classes of secondary metabolites in plants is induced by the stress hormone jasmonate. The gene for ORCA3, a jasmonate-responsive APETALA2 (AP2)-domain transcription factor from Catharanthus roseus, was isolated by transferred DNA activation tagging. Orca3 overexpression resulted in enhanced expression of several metabolite biosynthetic genes and, consequently, in increased accumulation of terpenoid indole alkaloids. Regulation of metabolite biosynthetic genes by jasmonate-responsive AP2-domain transcription factors may link plant stress responses to changes in metabolism.
植物中许多类次生代谢产物的生物合成是由应激激素茉莉酸诱导的。通过转座子激活标签法从长春花中分离出了ORCA3基因，它是一种茉莉酸响应型APETALA2（AP2）结构域转录因子。Orca3的过表达导致几种代谢产物生物合成基因的表达增强，进而导致萜类吲哚生物碱的积累增加。茉莉酸响应型AP2结构域转录因子对代谢产物生物合成基因的调控可能将植物应激反应与代谢变化联系起来。
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