Leeb T, Breen M, Brenig B
Institute of Veterinary Medicine, University of Göttingen, Göttingen, Germany.
Cytogenet Cell Genet. 2000;89(1-2):98-100. doi: 10.1159/000015573.
Analysis of genomic sequence from canine chromosome 20q15.1-->q15.2 revealed the presence of two closely linked genes. The two genes represent the corresponding canine orthologs of human aminomethyltransferase (AMT) and the human T-cell leukemia translocation associated (TCTA) gene. Aminomethyltransferase or glycine cleavage system T-protein is an important enzyme in glycine metabolism. The reported canine AMT gene spans 5 kb and consists of nine exons. It encodes a protein of 403 amino acids with 88% identity to human aminomethyltransferase. Human TCTA is located on 3p21 near the breakpoint of a t(1;3) translocation observed in some cancer cell lines. The 4-kb canine TCTA gene consists of three exons and probably represents a pseudogene. It is located adjacent to AMT and very close to DAG1 and BSN.
对犬类20号染色体q15.1至q15.2区域的基因组序列分析显示存在两个紧密连锁的基因。这两个基因分别代表人类氨基甲基转移酶（AMT）和人类T细胞白血病易位相关（TCTA）基因的相应犬类直系同源基因。氨基甲基转移酶或甘氨酸裂解系统T蛋白是甘氨酸代谢中的一种重要酶。报道的犬类AMT基因跨度为5kb，由九个外显子组成。它编码一种403个氨基酸的蛋白质，与人类氨基甲基转移酶的同源性为88%。人类TCTA位于3p21，靠近在一些癌细胞系中观察到的t(1;3)易位的断点。4kb的犬类TCTA基因由三个外显子组成，可能代表一个假基因。它位于AMT附近，与DAG1和BSN非常接近。
