Baruch D I
Laboratory of Parasitic Diseases, NIAID/NIH, Bethesda, MD 20892-0425, USA.
Baillieres Best Pract Res Clin Haematol. 1999 Dec;12(4):747-61. doi: 10.1053/beha.1999.0051.
Antigenic variation, rosetting and cytoadhesion are key determinants in the survival and virulence of the malaria parasite Plasmodium falciparum. These properties reside in a multigene protein family called P. falciparum erythrocyte membrane protein I (PfEMPI), encoded by the large and diverse var gene family. PfEMPI plays a central role in the biology of P. falciparum and its interaction with the human host. The molecular mechanism and the domains involved in cytoadherence, rosetting and antigenic variation are beginning to unfold. Domains mediating rosetting and adhesion to several key host receptors have already been identified. Understanding the role of PfEMPI in the pathogenesis and survival of malaria parasites is the key for the development of anti-adhesion vaccines and therapeutics to reduce the mortality and morbidity of P. falciparum infections.
抗原变异、红细胞凝聚和细胞黏附是恶性疟原虫生存和毒力的关键决定因素。这些特性存在于一个多基因蛋白家族中，称为恶性疟原虫红细胞膜蛋白I（PfEMPI），由庞大且多样的var基因家族编码。PfEMPI在恶性疟原虫的生物学特性及其与人类宿主的相互作用中起着核心作用。细胞黏附、红细胞凝聚和抗原变异所涉及的分子机制和结构域正开始被揭示。介导红细胞凝聚以及与几种关键宿主受体黏附的结构域已被确定。了解PfEMPI在疟原虫发病机制和生存中的作用是开发抗黏附疫苗和治疗方法以降低恶性疟原虫感染死亡率和发病率的关键。
