Kowalska I, Kinalski M, Wołczyński S, Straczkowski M, Kinalska I, Szamatowicz M
Kliniki Endokrynologii Akademii Medycznej w Białymstoku.
Ginekol Pol. 1999 Jun;70(6):428-32.
The aim of the present study was to estimate the leptin role in the pathogenesis of polycystic ovary syndrome.
The study was carried out in 21 obese women with PCO, 18 obese women without menstrual disturbances and 9 normal-weight healthy women.
In all patients antropomethric parameters: weight, height, % of body fat, waist and hip girths were measured and than BMI and WHR were calculated. Plasma concentrations of leptin, insulin, LH, FSH, testosterone, cortisol, PRL, estradiol were estimated.
There were no statistical significant difference between plasma leptin concentrations in obese patients with PCO in comparison to obese women with normal menstrual cycle. In both groups of obese patients plasma leptin concentrations was significantly higher than in control group (p < 0.001, p < 0.001). There were significant correlation between plasma leptin and % body fat, BMI and waist girth in all studied groups.
We conclude that leptin is not directly involved in observed hormonal disturbances in polycystic ovary syndrome. The main predictor of plasma leptin concentrations in patients with PCO is amount of body fat.
本研究旨在评估瘦素在多囊卵巢综合征发病机制中的作用。
该研究对21名患有多囊卵巢的肥胖女性、18名无月经紊乱的肥胖女性和9名体重正常的健康女性进行。
测量所有患者的人体测量参数：体重、身高、体脂百分比、腰围和臀围，然后计算体重指数（BMI）和腰臀比（WHR）。估算血浆中瘦素、胰岛素、促黄体生成素（LH）、促卵泡生成素（FSH）、睾酮、皮质醇、泌乳素（PRL）、雌二醇的浓度。
患有多囊卵巢的肥胖患者与月经周期正常的肥胖女性相比，血浆瘦素浓度无统计学显著差异。两组肥胖患者的血浆瘦素浓度均显著高于对照组（p < 0.001，p < 0.001）。在所有研究组中，血浆瘦素与体脂百分比、BMI和腰围之间均存在显著相关性。
我们得出结论，瘦素并不直接参与多囊卵巢综合征中观察到的激素紊乱。多囊卵巢综合征患者血浆瘦素浓度的主要预测因素是体脂量。
