Kinalski M, Kowalska I, Wołczyński S, Straczkowski M, Telejko B, Kinalska I, Szamatowicz M
Instytutu Połoznictwa i Chorób Kobiecych, Akademii Medycznej w Białymstoku.
Ginekol Pol. 1999 Jun;70(6):419-26.
The aim of the present study was to estimate the role of insulin in the pathogenesis of polycystic ovary syndrome.
The study was carried out in 21 obese women with PCO, 18 obese women without menstrual disturbances and 9 normal-weight healthy women.
In all patients antropomethric parameters: weight, height, % of body fat, waist and hip girths were measured and than BMI and WHR were calculated. Oral glucose tolerance test after 75 g glucose was done after overnight fast. Plasma glucose and insulin were measured in 0 min, 60 min and 120 min of the test. The concentrations of IGF-I, IGFBP-1, SHBG, LH, FSH, testosterone, cortisol, PRL, estradiol, were estimated.
There was statistical significant difference between plasma insulin concentrations in obese patients with PCO in comparison to obese women with normal menstrual cycle (p < 0.05) and control group (p < 0.001). The concentrations of IGFBP-1 and SHBG were similar in both groups of obese patients and differ markedly in comparison to the control group. There were significant correlation between plasma insulin and % body fat, BMI and waist girth in all studied groups.
We conclude that in obese women with PCO insulin influence ovarian androgen production and decreases the serum SHBG and IGFBP-1 which could contribute in the augmentation of the symptoms of PCO.
本研究旨在评估胰岛素在多囊卵巢综合征发病机制中的作用。
该研究对21名患有多囊卵巢的肥胖女性、18名无月经紊乱的肥胖女性和9名体重正常的健康女性进行。
测量所有患者的人体测量参数：体重、身高、体脂百分比、腰围和臀围，然后计算体重指数（BMI）和腰臀比（WHR）。在过夜禁食后进行75克葡萄糖口服葡萄糖耐量试验。在试验的0分钟、60分钟和120分钟测量血浆葡萄糖和胰岛素。评估胰岛素样生长因子-I（IGF-I）、胰岛素样生长因子结合蛋白-1（IGFBP-1）、性激素结合球蛋白（SHBG）、促黄体生成素（LH）、促卵泡生成素（FSH）、睾酮、皮质醇、泌乳素（PRL）、雌二醇的浓度。
患有多囊卵巢的肥胖患者与月经周期正常的肥胖女性（p < 0.05）及对照组（p < 0.001）相比，血浆胰岛素浓度存在统计学显著差异。两组肥胖患者的IGFBP-1和SHBG浓度相似，与对照组相比有明显差异。在所有研究组中，血浆胰岛素与体脂百分比、BMI和腰围之间存在显著相关性。
我们得出结论，在患有多囊卵巢的肥胖女性中，胰岛素影响卵巢雄激素的产生，并降低血清SHBG和IGFBP-1，这可能会加重多囊卵巢综合征的症状。
