Wong L, Chung Y F, Wong C Y
Department of Obstetrics and Gynaecology, Singapore General Hospital, Singapore.
Ann Acad Med Singap. 2000 Mar;29(2):198-200.
Isolated single-duct nipple discharge is worrying and poses a surgical dilemma. Factors predicting malignancy are controversial.
Retrospective review of 92 consecutive microdochectomies for single-duct nipple discharge in a tertiary referral centre over 8 years.
The commonest causes were ductal papilloma (52%) and fibrocystic diseases of the breast (21%). Five (5%) patients had breast carcinoma, of whom only 1 had an invasive component. The median age of these patients was 43 years (range 26 to 72 years) which was similar to median age of the whole cohort. Sixty-seven (73%) patients presented with blood-stained nipple discharge. The 5 patients with breast carcinoma had blood-stained discharge. Mammography was abnormal in 1 out of 4 patients in the carcinoma group.
The incidence of breast carcinoma in patients presenting with isolated single-duct nipple discharge was low (5%) among Singaporean women. There was no reliable predictors of malignancy, though all patients with carcinoma presented with blood-stained discharge. Microdochectomy still remains an effective treatment for nipple discharge both for cure and diagnosis.
孤立性单导管乳头溢液令人担忧,且带来手术难题。预测恶性肿瘤的因素存在争议。
对一家三级转诊中心8年间连续92例因单导管乳头溢液行微小乳管切除术的病例进行回顾性研究。
最常见病因是导管内乳头状瘤(52%)和乳腺纤维囊性疾病(21%)。5例(5%)患者患有乳腺癌,其中仅1例有浸润成分。这些患者的中位年龄为43岁(范围26至72岁),与整个队列的中位年龄相似。67例(73%)患者出现血性乳头溢液。5例乳腺癌患者均有血性溢液。乳腺癌组4例患者中有1例乳房X线摄影异常。
在新加坡女性中,孤立性单导管乳头溢液患者的乳腺癌发病率较低(5%)。尽管所有乳腺癌患者均有血性溢液,但尚无可靠的恶性肿瘤预测指标。微小乳管切除术对于乳头溢液的治疗和诊断仍然是一种有效的方法。