Min Y G, Lee K S
Department of Otorhinolaryngology, Seoul National University College of Medicine, Korea.
J Korean Med Sci. 2000 Jun;15(3):255-9. doi: 10.3346/jkms.2000.15.3.255.
Since the last decade, new insights into inflammatory processes have become possible by investigating the pattern of cytokines in acute and chronic sinus diseases. This review aims to update and discuss the findings of in vitro and in vivo studies concerning the role of cytokines in sinusitis and nasal polyposis. The proinflammatory cytokines interleukin-1beta, interleukin-6 and the neutrophil-chemoattractant interleukin-8 may play a major role in acute sinusitis, as shown in viral and allergic rhinitis. In chronic sinusitis interleukin-3 dominates the cytokine profiles, giving support to a variety of inflammatory cells. Interleukin-5 is a key protein in the pathogenesis of nasal polyposis. Activation and survival of eosinophils in nasal polyps are thought to be regulated by interleukin-5. Further investigation of cytokine expression patterns in inflammatory sinus diseases will lead to a better understanding of their pathogenesis and to a development of new therapeutic modality.
在过去十年中，通过研究急性和慢性鼻窦疾病中细胞因子的模式，对炎症过程有了新的认识。本综述旨在更新和讨论关于细胞因子在鼻窦炎和鼻息肉中作用的体外和体内研究结果。促炎细胞因子白细胞介素-1β、白细胞介素-6和中性粒细胞趋化因子白细胞介素-8可能在急性鼻窦炎中起主要作用，如在病毒性和过敏性鼻炎中所示。在慢性鼻窦炎中，白细胞介素-3主导细胞因子谱，支持多种炎症细胞。白细胞介素-5是鼻息肉发病机制中的关键蛋白。鼻息肉中嗜酸性粒细胞的激活和存活被认为受白细胞介素-5调节。进一步研究炎症性鼻窦疾病中的细胞因子表达模式将有助于更好地理解其发病机制，并开发新的治疗方法。
