Minami Masaaki, Konishi Toru, Takase Hiroshi, Jiang Zhixia, Arai Tetsuya, Makino Toshiaki
Department of Bacteriology, Graduate School of Medical Sciences, Nagoya City University, 1 Kawasumi, Mizuho-ku, Nagoya, Japan.
Department of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, Japan.
Evid Based Complement Alternat Med. 2017;2017:4293291. doi: 10.1155/2017/4293291. Epub 2017 Jul 20.
causes sinusitis. The general treatment of sinusitis is by using antibiotics; however, one of their serious problems is the attenuation of their effect. Shin'iseihaito (Xinyiqingfeitang), a formula of Japanese traditional Kampo medicine, has been used for the treatment of sinusitis in Japan. In this study, we investigated the efficacy of Shin'iseihaito against -caused sinusitis in mice. Oral administration of Shin'iseihaito extract (SSHT) decreased the nasal colonization of in both prophylactic and therapeutic treatments, respectively, and the former was more effective than the latter. Histopathological analysis revealed that the epithelial tissue from -infected nose under SSHT treatment recovered the tissue destruction in comparison to infected nose. We also confirmed this result by scanning electron microscopic analysis. Murine peritoneal macrophages from SSHT-treated mice had significant phagocytic activity in comparison to those from untreated group. We also found that tumor necrosis factor-, interleukin-1, interleukin-6, and monocyte chemotactic protein-1 levels and the migration of macrophages from -infected mice with the treatment with SSHT were increased compared to those from untreated group. Our data suggest that Shin'iseihaito may be useful for the treatment of -induced sinusitis.
引发鼻窦炎。鼻窦炎的一般治疗方法是使用抗生素；然而，它们的一个严重问题是效果减弱。日本传统汉方药物方剂“辛夷清肺汤”（Shin'iseihaito）在日本已被用于治疗鼻窦炎。在本研究中，我们调查了辛夷清肺汤对小鼠由[具体病因未明确]引发的鼻窦炎的疗效。口服辛夷清肺汤提取物（SSHT）在预防性和治疗性治疗中分别降低了[具体病菌未明确]在鼻腔的定植，且前者比后者更有效。组织病理学分析显示，与感染的鼻子相比，SSHT治疗下由[具体病菌未明确]感染的鼻子的上皮组织恢复了组织破坏。我们还通过扫描电子显微镜分析证实了这一结果。与未处理组相比，SSHT处理的小鼠的小鼠腹膜巨噬细胞具有显著的吞噬活性。我们还发现，与未处理组相比，用SSHT治疗的由[具体病菌未明确]感染的小鼠的肿瘤坏死因子-α、白细胞介素-1、白细胞介素-6和单核细胞趋化蛋白-1水平以及巨噬细胞的迁移增加。我们的数据表明，辛夷清肺汤可能对治疗由[具体病因未明确]引起的鼻窦炎有用。
