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银杏内酯B的烷基和烷氧羰基衍生物：血小板活化因子抑制活性的合成与生物学评价

Alkyl and alkoxycarbonyl derivatives of ginkgolide B: synthesis and biological evaluation of PAF inhibitory activity.

作者信息

Hu L, Chen Z, Xie Y, Jiang Y, Zhen H

机构信息

Shanghai Institute of Materia Medica, Academia Sinica, People's Republic of China.

出版信息

Bioorg Med Chem. 2000 Jun;8(6):1515-21. doi: 10.1016/s0968-0896(00)00085-7.

DOI:10.1016/s0968-0896(00)00085-7
PMID:10896127
Abstract

Alkyl and alkoxycarbonyl derivatives 6-24 of ginkgolide B, prepared in one step from ginkgolide B through alkylation and acylation and evaluated for their in vitro ability to inhibit the PAF-induced aggregation of rabbit platelets, show equivalent or superior activities to ginkgolide B.

摘要

银杏内酯B的烷基和烷氧羰基衍生物6 - 24是通过烷基化和酰化反应由银杏内酯B一步制备而成，并对其抑制血小板活化因子（PAF）诱导的兔血小板聚集的体外能力进行了评估，结果显示它们具有与银杏内酯B相当或更优的活性。

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