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The expression of glucose regulated protein-94 in colorectal carcinoma cells treated by sodium butyrate.

作者信息

Wu Y D, Song J D

机构信息

Key Laboratory of Cell Biology, Ministry of Public Health of China.

出版信息

Cell Res. 2000 Jun;10(2):115-25. doi: 10.1038/sj.cr.7290041.

DOI:10.1038/sj.cr.7290041
PMID:10896173
Abstract

The expression of glucose regulated protein 94 (GRP94) during the treatment of human colorectal carcinoma cell line-Clone A cells with sodium butyrate was studied. Sodium butyrate (SB) can cause functional and morphological effects on Clone A cells including growth arrest at G0/G1 stage and cell differentiation as observed by morphological changes, MTT and flow cytometry assays, as well as reduced Grp94 gene expression as shown by Northern blot and Western blot assays. The possible mechanism of the correlation between Grp94 gene expression and tumor growth inhibition and cell differentiation is briefly discussed.

摘要

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Correlation between clinicopathology and expression of heat shock protein 70 and glucose-regulated protein 94 in human colonic adenocarcinoma.
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