Mansourati J, Da Costa A, Munier S, Mercier B, Tardy B, Ferec C, Isaaz K, Blanc J J
Cardiology Department of Brest, North Hospital of Saint Etienne, France.
Thromb Haemost. 2000 Jun;83(6):822-5.
Factor V Leiden is associated with an increased risk of venous thrombosis and myocardial infarction in young women, but not in men in this latter case. The aim of this study was to evaluate the prevalence of this mutation in patients with myocardial infarction but normal coronary angiography. We compared 3 groups of patients: one group consisted of 107 patients with premature myocardial infarction but no significant coronary artery stenosis; another group of 244 patients with myocardial infarction and significant coronary artery stenosis; a third group of 400 healthy controls. Factor V Leiden was found in 13 patients (12.1%) who had a myocardial infarction without significant coronary artery stenosis, 11 patients (4.5%) who had a myocardial infarction with significant coronary artery stenosis (p = 0.01) and in 20 controls (5%) (p = 0.01). Odds ratio associated with factor V Leiden were respectively 2.93 (CI95: 1.18-7.31 ) and 2.63 (CI95: 1.19-5.78) when we compared myocardial infarction patients without significant coronary artery stenosis to controls or to patients with significant coronary artery stenosis. In myocardial infarction patients without significant coronary artery stenosis, prevalence of factor V Leiden is significantly higher than in controls. This new finding supports the hypothesis that thrombosis plays a key role in this selected situation.
莱顿V因子与年轻女性静脉血栓形成和心肌梗死风险增加相关，但在男性中则不然。本研究的目的是评估冠状动脉造影正常的心肌梗死患者中这种突变的患病率。我们比较了3组患者：一组由107例早发心肌梗死但无明显冠状动脉狭窄的患者组成；另一组为244例有心肌梗死且有明显冠状动脉狭窄的患者；第三组为400名健康对照者。在13例（12.1%）无明显冠状动脉狭窄的心肌梗死患者、11例（4.5%）有明显冠状动脉狭窄的心肌梗死患者（p = 0.01）以及20例对照者（5%）（p = 0.01）中发现了莱顿V因子。当我们将无明显冠状动脉狭窄的心肌梗死患者与对照者或有明显冠状动脉狭窄的患者进行比较时，与莱顿V因子相关的比值比分别为2.93（95%CI：1.18 - 7.31）和2.63（95%CI：1.19 - 5.78）。在无明显冠状动脉狭窄的心肌梗死患者中，莱顿V因子的患病率显著高于对照者。这一新发现支持了血栓形成在这种特定情况下起关键作用的假说。
