Pérez-Martínez C, García Fernández R A, Reyes Avila L E, Pérez-Pérez V, González N, García-Iglesias M J
Vet Pathol. 2000 Jul;37(4):350-3. doi: 10.1354/vp.37-4-350.
A 12-year-old male Boxer dog presented with a 5 x 5 x 7-cm partially encapsulated mass in the right mandibular salivary gland. Histologically, the mass was composed of neoplastic epithelial and mesenchymal cells. The mesenchymal component consisted of two cell populations arranged in different patterns: coalescing nodules of neoplastic mononuclear cells with rare osteoid and numerous osteoclastlike giant cells; and sheets of neoplastic spindle cells intermingled with neoplastic epithelial cells and containing osteoid and well-formed bone trabeculae lined by osteoblasts and few osteoclastlike giant cells. On the basis of these histological features, two malignant salivary tumors were diagnosed: a malignant fibrous histiocytoma (giant cell type) and a malignant mixed tumor. Immunohistochemical studies demonstrated keratin 5 and 8 expression by the neoplastic epithelial cells, indicating a probable salivary ductal origin, and vimentin expression by all mesenchymal elements, suggesting a fibroblastic line of differentiation.
一只12岁的雄性拳师犬右侧下颌唾液腺出现一个5×5×7厘米的部分包膜肿块。组织学上，该肿块由肿瘤性上皮细胞和间充质细胞组成。间充质成分由两种以不同模式排列的细胞群组成：肿瘤性单核细胞融合结节，伴有罕见类骨质和大量破骨细胞样巨细胞；以及成片的肿瘤性梭形细胞，与肿瘤性上皮细胞混合，含有类骨质和由成骨细胞衬里且有少量破骨细胞样巨细胞的成熟骨小梁。基于这些组织学特征，诊断出两种恶性唾液腺肿瘤：恶性纤维组织细胞瘤（巨细胞型）和恶性混合瘤。免疫组织化学研究显示肿瘤性上皮细胞表达角蛋白5和8，表明可能起源于唾液导管，所有间充质成分均表达波形蛋白，提示为成纤维细胞分化谱系。
