Animal Specialty & Emergency Center of Brevard, Melbourne, FL, USA.
Animal Dental Center, Towson, MD, USA.
J Feline Med Surg. 2023 Aug;25(8):1098612X231189973. doi: 10.1177/1098612X231189973.
Salivary gland adenocarcinoma, of major or minor salivary gland origin, is an uncommon tumor in cats. This article describes the clinical features, morbidity and survival rates of four cats with salivary gland adenocarcinoma arising from minor salivary gland tissue. Medical records from a private multicenter dentistry and oral surgery practice were reviewed for the period between 2007 and 2021. Four cats were included in this retrospective case series study, with oral masses on either the right or left caudal mandibular labial buccal mucosa. The inclusion criteria included a diagnosis of salivary gland adenocarcinoma in an anatomical location with lack of involvement of a major salivary gland, complete medical history and a follow-up of at least 6 months. The age range of the cats was 9-15 years; three of the cats were castrated males and one was a spayed female. Curative intent surgery was performed in three cats, whereas palliative surgery (debulking) owing to extensive soft tissue invasion was performed in one cat. Survival times were in the range of 210-1730 (mean 787) days. All four cats were euthanized owing to local recurrence and decreased quality of life, regardless of treatment modality.
There are limited documented studies reporting the prevalence of salivary gland neoplasia affecting minor disseminated glands in the oral cavity of feline patients. Salivary gland adenocarcinoma should be a differential in cats presenting with caudal labial masses. Surgical resection has been the recommended treatment for salivary gland neoplasia of major salivary gland origin. According to this current case series, we propose that early aggressive surgical treatment with wide surgical margins should be performed for cats with salivary gland adenocarcinoma of minor salivary gland origin. Surgery increased the quality and duration of life; however, each patient was euthanized owing to local recurrence and morbidity.
主要或次要涎腺来源的涎腺癌在猫中是一种罕见的肿瘤。本文描述了 4 例源自小涎腺组织的涎腺癌的猫的临床特征、发病率和存活率。对 2007 年至 2021 年期间一家私立多中心牙科和口腔外科诊所的病历进行了回顾性病例系列研究。本回顾性病例系列研究纳入了 4 例猫，口腔肿块位于下颌唇颊侧粘膜的右侧或左侧尾部。纳入标准包括在缺乏大涎腺参与的解剖位置诊断为涎腺癌、完整的病史和至少 6 个月的随访。猫的年龄范围为 9-15 岁；3 只为去势雄性，1 只为去势雌性。3 只猫行根治性手术，1 只因广泛软组织侵犯而行姑息性手术（减瘤术）。存活时间范围为 210-1730（平均 787）天。所有 4 只猫均因局部复发和生活质量下降而被安乐死，无论治疗方式如何。
目前很少有文献报道猫口腔小涎腺弥漫性肿瘤的涎腺肿瘤发病率。涎腺癌应作为尾部唇侧肿块猫的鉴别诊断。手术切除一直是主要涎腺来源的涎腺肿瘤的推荐治疗方法。根据本病例系列研究，我们建议对小涎腺来源的涎腺癌猫早期进行广泛手术切除，以获得良好的预后。手术提高了生活质量和延长了生存时间；然而，每个病例都因局部复发和发病率而被安乐死。
