Ghislain P D, Ghislain E
Service de Dermatologie, Centre hospitalier, Louvain, Belgique.
Ann Med Interne (Paris). 2000 May;151(3):227-9.
We report a case of angioedema limited to the nape of the neck. The symptoms occurred every morning for fifteen days, two or three hours after taking aspirin. The patient took salicylic acid, 100mg per day, orally for two years. The angioedema occurred alone, without urticaria. When aspirin was stopped, the symptoms disappeared. A few weeks later, the patient took napoxen, with occurrence of more pronounced symptoms. The causality score was I3 for both drugs. The most common side-effects of aspirin intake are asthma and urticaria/angioedema. The mechanism of this hypersensitivity is unknown. There are numerous cross-reactions between aspirin and other NSAIDs. This case points out the importance of accurate history taking concerning self-medication for the diagnosis of angioedema.
我们报告一例局限于颈部后侧的血管性水肿病例。症状持续了十五天，每天早晨出现，在服用阿司匹林两到三小时后发作。患者口服水杨酸，每日100毫克，持续了两年。血管性水肿单独出现，无荨麻疹。停用阿司匹林后，症状消失。几周后，患者服用萘普生，症状更为明显。两种药物的因果关系评分为I3。服用阿司匹林最常见的副作用是哮喘和荨麻疹/血管性水肿。这种超敏反应的机制尚不清楚。阿司匹林与其他非甾体抗炎药之间存在众多交叉反应。该病例指出了准确了解自我用药史对于血管性水肿诊断的重要性。
