Botey J, Navarro C, Aulesa C, Marín A, Eseverri J L
Servicio de Alergia e Inmunologia Clinica, Hospital Infantil de La Vall D'Hebron, Universidad Autonoma de Barcelona, Spain.
Allergol Immunopathol (Madr). 1988 Jan-Feb;16(1):43-7.
From the report of Hirschberg, only 3 years after aspirin synthesis, there have been numerous works dedicated to showing the different types of adverse reactions found following aspirin administration. However, there are few publications on the process of urticaria and/or acute angioedema induced by ASA and few reported cases were found in children. Thus, we present 6 atopic children with urticaria and/or angioedema related with ASA. A carefully detailed history, oral provocation with ASA, oral provocation with other NSAI and HBDT with ASA were done to all of them. The oral provocation with ASA was positive in 5 of the 6 cases. The provocations with the rest of the NSAI and tartrazine and sodium benzoate were negative in all of the patients. The HBDT was positive in 5 of the cases. In conclusion, we insist that aspirin intolerance is not infrequent in infancy and it is not rare to see urticaria and or angioedema, in spite of the fact that asthmatics, atopics or non atopics, usually present as bronchospasm. We also believe that the HBDT can be a method of diagnosis used in these cases.
从赫希贝格的报告来看，阿司匹林合成仅3年后，就有大量研究致力于揭示服用阿司匹林后出现的不同类型不良反应。然而，关于阿司匹林诱发荨麻疹和/或急性血管性水肿过程的出版物较少，儿童中报道的病例也很少。因此，我们报告6例患有与阿司匹林相关的荨麻疹和/或血管性水肿的特应性儿童。我们对所有患儿进行了详细的病史询问、阿司匹林口服激发试验、其他非甾体抗炎药口服激发试验以及阿司匹林组胺释放试验。6例中有5例阿司匹林口服激发试验呈阳性。其余非甾体抗炎药、酒石黄和苯甲酸钠激发试验在所有患者中均为阴性。5例组胺释放试验呈阳性。总之，我们坚持认为阿司匹林不耐受在婴儿期并不少见，尽管哮喘患者、特应性或非特应性患者通常表现为支气管痉挛，但出现荨麻疹和/或血管性水肿的情况并不罕见。我们还认为组胺释放试验可作为这些病例的一种诊断方法。
