Oguogho A, Aghajanian A A, Sinzinger H
Department of Nuclear Medicine, University of Vienna, Austria.
Lymphology. 2000 Jun;33(2):62-6.
(Iso)-eicosanoids appear to play a pivotal role in lymphatic contractility. Because prostaglandin (PG)I2, an arachidonic acid (20:4) metabolite, is a key substance generated by human lymphatics, both from exogenous and endogenous substrates, it is reasonable to assume that altered nutritional intake of precursor fatty acids (FA) influences formation of respective eicosanoids qualitatively and quantitatively, and thereby modify its biological effects on human lymphatics. We, therefore, examined the effect of 2 other FA-precursors, dihomo-gamma-linolenic (20:3) and eicosapentaenoic acid (20:5) on the formation of the respective PG-metabolites in human lymphatics removed from the legs in patients undergoing amputation after traumatic injury. 20:3 and 20:5 were poorer substrates to form PGs. Because these PGs exert different biological actions and their synthesis may be altered by vascular environmental risk factors such as cigarette smoking, diabetes mellitus, hyperlipidemia, and availability of FA precursors and therefore nutrition, PGs may profoundly modulate the lymphatic contractile response under a variety of circumstances. The full effect of all the formed compounds of the 1- and 3-series PGs on lymph vessel contractility, however, still needs to be tested.
（异）二十碳烷类化合物似乎在淋巴管收缩性中起关键作用。由于前列腺素（PG）I2是一种花生四烯酸（20:4）代谢产物，是人体淋巴管由外源性和内源性底物生成的关键物质，因此可以合理推测，前体脂肪酸（FA）营养摄入的改变会在质量和数量上影响相应二十碳烷类化合物的形成，从而改变其对人体淋巴管的生物学效应。因此，我们研究了另外两种FA前体，二高-γ-亚麻酸（20:3）和二十碳五烯酸（20:5）对创伤后截肢患者腿部切除的人体淋巴管中相应PG代谢产物形成的影响。20:3和20:5是形成PG的较差底物。由于这些PG发挥不同的生物学作用，其合成可能会受到血管环境危险因素的影响，如吸烟、糖尿病、高脂血症以及FA前体的可用性进而营养状况，因此PG可能在多种情况下深刻调节淋巴管收缩反应。然而，1-和3-系列PG所有生成化合物对淋巴管收缩性的全面影响仍有待测试。
